Fwd: Microgravity accelerates biological aging

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From: "Gary Johnson" <gjohnson144@comcast.net>
Date: November 6, 2013 10:50:35 AM CST
To: "Gary Johnson" <gjohnson144@comcast.net>
Subject: FW: Microgravity accelerates biological aging

 

Astronauts in microgravity face risk of accelerated biological aging

Oct. 31, 2013  |  6:36 PM

BETHESDA, Md., Oct. 31 (UPI) -- Microgravity experienced by astronauts in space accelerates biological aging and cardiovascular disease by affecting blood vessel cells, a U.S. journal reports.

Experiments conducted on the International Space Station found microgravity accelerated the biological aging of endothelial cells, which line the inner surfaces of blood vessels, researchers said in a study published in the journal of the Federation of American Societies for Experimental Biology.

A comparison of space-flown endothelial cells to endothelial cells cultured under normal gravity for differences in gene expression and/or in the profile of secreted proteins found the space-flown cells differentially expressed more than 1,000 genes and secreted high amounts of pro-inflammatory cytokines, inducing significant oxidative stress, the researchers said.

The findings suggest possible ways to improve the health of all people, not just astronauts, they said.

"Understanding the cellular and molecular events of senescence might help in finding preventive measures that are useful to improve the quality of life of millions of people," said Silvia Bradamante, a researcher involved in the work from the Institute of Molecular Science and Technologies in Milan, Italy. "Our study further supports the role of oxidative stress in accelerating aging and disease."

Experts said further research should focus on the biological risks facing astronauts.

"As we plan to send people deeper into space than ever before, and for longer flights, we've got to make sure that they remain in best health possible," said Gerald Weissmann, editor in chief of The FASEB Journal. "We've evolved to rely on gravity to regulate our biology, and without it, our tissues become confused. Worst of all: they age faster!"

 

© 2013 United Press International, Inc. All Rights Reserved. 

 

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31-Oct-2013
FASEB Journal

Houston we have a problem: Microgravity accelerates biological aging
As nations strive to put humans farther into space for longer periods of time, the real loser in this new space race could be the astronauts themselves. That's because experiments conducted on the International Space Station show that microgravity accelerates cardiovascular disease and the biological aging of these cells. These findings are presented in a new research report published in Nov. 2013 issue of The FASEB Journal.

 

 

 

31-Oct-2013

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

Houston we have a problem: Microgravity accelerates biological aging

New research in The FASEB Journal suggests that gravitational unloading significantly impairs the function of endothelial cells, as evidenced by gene expression studies conducted in space

Bethesda, MD—As nations strive to put humans farther into space for longer periods of time, the real loser in this new space race could be the astronauts themselves. That's because experiments conducted on the International Space Station involving cells that line the inner surfaces of blood vessels (endothelial cells) show that microgravity accelerates cardiovascular disease and the biological aging of these cells. These findings are presented in a new research report published in November 2013 issue of The FASEB Journal.

"Understanding the cellular and molecular events of senescence might help in finding preventive measures that are useful to improve the quality of life of millions of people," said Silvia Bradamante, a researcher involved in the work from the CNR-ISTM, Institute of Molecular Science and Technologies in Milan, Italy. "Our study further supports the role of oxidative stress in accelerating aging and disease."

In this report, Bradamante and colleagues examined endothelial cells in real microgravity aboard the International Space Station and conducted deep gene expression and protein analysis on the cells. They compared space-flown endothelial cells to endothelial cells cultured under normal gravity, looking for differences in gene expression and/or in the profile of secreted proteins. Space-flown cells differentially expressed more than 1,000 genes and secreted high amounts of pro-inflammatory cytokines. Ultimately, this induced significant oxidative stress, causing inflammation among endothelial cells, which in turn, led to atherosclerosis and cell senescence (biological aging).

"As we plan to send people deeper into space than ever before, and for longer flights, we've got to make sure that they remain in best health possible," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've evolved to rely on gravity to regulate our biology, and without it, our tissues become confused. Worst of all: they age faster!"

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Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 27 societies with more than 110,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Silvia Versari, Giulia Longinotti, Livia Barenghi, Jeanette Anne Marie Maier, and Silvia Bradamante. The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment. FASEB J November 2013 27:4466-4475; doi:10.1096/fj.13-229195 ; http://www.fasebj.org/content/27/11/4466.abstract

 

 

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